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Ha˚kanson 1Department of Pharmacology, Institute of Physiological Sciences, University of Lund, So¨lvegatan 10, Lund, Sweden Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor.These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach. ECL cells are scattered in the oxyntic glands, often in direct contact with parietal cells. The number of ECL cells in mammal stomachs varies greatly with species. ECL cells constitute 65% of the endocrine cell mass in rat oxyntic mucosa, whereas D cells represent a minor population of only 2–5% . Flag as Inappropriate Moreover, a proportion of diffuse gastric carcinomas may originate from ECL cells . Neuroendocrine or enterochromaffin cells were first de- scribed in the stomach  multiple tumours have been reported.5 8-12.

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Abstract: The term “enterochromaffin cell” was introduced more than 100 years ago. The cells that are morphologically similar to the enterochromaffin cells have been referred to as “enterochromaffin-like The ECL cells in the stomach produce, store and secrete a variety of secretory products, such as histamine and chromogranin A-derived peptides (e.g. pancreastatin). The functional significance of the ECL cells can be expected to reflect the nature/bioactivity of the secreted products.

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Parietal cells are the exocrine cells of the stomach that secrete hydrochloric acid (HCl). · Control of Parietal Cell Secretion · Chief  Parietal cells can be found in your stomach; they're tasked with making hydrochloric acid (HCl) and intrinsic factor (IF) after you've finished eating. Hydrochloric  Apr 4, 2019 Physiology of gastric acid secretion · The stomach consists of two functional areas; oxyntic and pyloric glands.

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It then Following addition of Amersham ECL Western Blotting.

Neuroendocrine cell proliferations of the stomach arise in various settings and show features ranging from hyperplasia to neoplasia; Alternate/Historical Names. WHO 2010 has changed back to neuroendocrine cell from endocrine cell for these lesions Endocrine cell hyperplasia and neoplasia are equivalent terms to those used below; Diagnostic Criteria The best-known component of gastric juice is hydrochloric acid, the secretory product of the parietal, or oxyntic cell. It is known that the capacity of the stomach to secrete HCl is almost linearly related to parietal cell numbers. When stimulated, parietal cells secrete HCl at a concentration of roughly 160 mM (equivalent to a pH of 0.8).
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The present report describes the e•ect of nine cholecystokinin2 (CCK2) receptor antagonists and one CCK1 receptor antagonist on the gastrin-evoked secretion of pancreastatin from isolated ECL cells. Anaesthetic agents inhibit gastrin-stimulated but not basal histamine release from rat stomach ECL cells 1P. Norle´n, 1M. Kitano, 1E. Lindstro¨m&*,1R.

We have studied CCK2 receptor-deficient mice and rats subjected to Not to be confused with Enterochromaffin cell. Enterochromaffin-like cells or ECL cells are a type of neuroendocrine cell found in the gastric glands of the gastric mucosa beneath the epithelium, in particular in the vicinity of parietal cells, that aid in the production of gastric acid via the release of histamine. “Enterochromaffin-like (ECL) cells” are a population of cells that are found in the gastric pits of the stomach luminal epithelium and secrete histamine.
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Although the ECL cells do not seem to operate under cholinergic control (Lindström et al. 1997; Lindström & Håkanson, 2001; Norlén et al. 2001), they do respond with secretory activation to a number of neuropeptides present in neurones in the stomach wall, e.g. pituitary adenylate cyclase‐activating peptide (PACAP) and vasoactive intestinal peptide (VIP) (Lindström et al. 1997; Zeng et Many of the endocrine cells in the stomach are poorly characterized with respect to physiological significance.

The cells respond to gastrin via cholecystokinin-2 (CCK2) receptors. A CCK2 receptor blockade was induced by treatment (for up to 8 weeks) with two receptor antagonists, YM022 and YF476. Changes in ECL-cell morphology were examined by immunocytochemistry and We recenlty studied the G‐cell, d ‐cell and ECL‐cell density in a case of G‐cell hyperplasia. The 70‐year‐old patient has been treated for persistent gastric ulcers with a markedly increased plasma gastrin (5600 pg/mL). The stomach was surgically resected because of the obstruction associated with ulcer scars.